Packaging 1 tab. (400 mg)
Zentel is an antiprotozoal and anthelmintic drug belonging to the benzimidazole carbomate group. It acts on intestinal and tissue forms of parasites, active on eggs, larvae and adult helminths. The drug inhibits the polymerization of tubulin, disrupting the metabolism of helminths and leading to their death.
Zentel is active against the following intestinal parasites:
nematodes - Trichuris trichiura, Cutaneous Larva Migrans, Ancylostoma duodenale, Ascaris lumbricoides, as well as Enterobius vermicularis, Strongyloides stercoralis, Necator americanus,
cestodes - Taenia solium, Hymenolepsis nan, Taenia saginata - porcine, pygmy and bovine tapeworm,
trematodes - Clonorchis sinensis, Opisthorchis viverrini,
protozoa - Giardia lamblia.
The drug is active against tissue parasites, including cystic echinococcosis, alveolar echinococcosis, which are caused by Echinococcus granulosus, Echinococcus multilocularis, respectively.
Zentel is effective in neurocysticercosis caused by Taenia solium larval invasion, capillariosis caused by Capillaria philippinensis, gnathostomosis caused by Gnathostoma spinigerum. The drug destroys or reduces the size of cysts of granular echinococcus. The number of non-viable cysts increases significantly after treatment. After the use of Zentel, the complete disappearance of cysts caused by Echinococcus multilocularis, or the stabilization of the disease, was noted.
The drug is poorly absorbed when administered orally. Fatty food significantly increases absorption. Zentel is metabolized in the liver. The main metabolite is albendazole sulfate, which is the main effective substance in the treatment of tissue infections. Ego T1/2 is about 8.5 hours. Elimination of the drug from cysts after long-term administration in high doses lasts for several weeks. Albendazole sulfate, as well as its metabolites, are excreted in the bile, a small part - in the urine.
Indications for use
Zentel is used in intestinal forms of helminthiasis: enterobiosis, hookworm, nekatorosis, hymenolepidosis, teniosis, strongyloidosis, ascariasis, trichocephalesis, clonorchosis, opistarchosis, giardiasis in children, as well as with each Larva Migrans syndrome - short-term treatment at low doses.
The drug is used for systemic helminthic infestations - long-term treatment with high doses.
For cystic echinococcosis caused by Echinococcus granulosus:
- if surgical intervention is impossible,
- before surgical intervention,
- in the postoperative period, if the preoperative treatment was short, if the prevalence of helminths is noted, if live forms are detected during the operation,
- after it is carried out for the purpose of diagnosis or percutaneous drainage therapy.
In alveolar echinococcosis caused by Echinococcus multilocularis:
- after surgical palliative treatment,
- in liver transplantation or radical surgical treatment.
In neurocysticercosis caused by Taenia solium larvae:
- in granulomatous lesions of the brain,
- in arachnoid cysts or intraventricular,
- when single or multiple cysts are detected,
- when racemose cysts.
Zentel is also used for capillariosis, which is caused by Capillaria philippinensis, gnathostomosis, which is caused by Gnathostoma spinigerum and other related species, trichinosis, which is caused by T. Pseudospiralis and Trichinella spiralis, toxocarosis, which is caused by Tochosaga canis and other related species.
How to use
Zentel is taken with food. If clinical improvement does not occur after 3 weeks, a second course of treatment is prescribed. Some patients, more often children, face difficulties when swallowing the tablet whole. In this case, it can be crushed or chewed, mixed with a small amount of water. Shake the resulting suspension before use.
For hookworm, enterobiasis, nekatorous ascariasis and trichocephaliasis, 400 mg of the drug - 1 tablet is taken once a day. With strongyloidosis, as well as teniosis, hymenolepidosis, 400 mg of the drug is taken per day for 3 days. With hymenolepidosis, a repeated course is carried out between the 10th and 21st day after the end of the previous course. For opistarchosis and clonorchosis, 400 mg is taken 3 times a day twice a day. For each Larva Migrans syndrome, 400 mg is taken per day, the treatment lasts up to 3 days. For children's giardiasis, the treatment is 5 days, 400 mg of the drug is taken per day.
Children aged 2-3 years are recommended to use Zentel in suspension orally. The drug should not be prescribed to children under 2 years of age. In case of enterobiasis, hookworm, as well as nekatorosis, ascariasis, trichocephalosis, a single dose of 10 ml of suspension. For children under 2 years of age, a single dose of 5 ml of suspension. With strongyloidosis, taeniosis, as well as hymenolepidosis, 10 ml of suspension for 3 days. With hymenolepidosis, the course is repeated between the 10th and 21st day after the end of the previous course. For clonorchosis and opistarchosis, 10 ml of suspension is prescribed twice a day for 3 days. For each Larva Migrans syndrome, 10 ml of suspension is taken per day, the treatment lasts up to 3 days. In case of giardiasis, treatment lasts 5 days, 10 ml of suspension is taken per day.
In the treatment of patients with impaired liver function, the drug is prescribed with caution, but it is not necessary to adjust the dose.
In case of renal insufficiency, dose adjustment of the drug is not necessary, since albendazole is excreted in small amounts by the kidneys.
For systemic helminthic infestations with long-term treatment in high doses, the drug should be taken with food. High doses of Zentel are not recommended for children under 6 years of age. The dose is set individually, depending on body weight, severity of infection and age. For patients weighing up to 60 kg, 400 mg of the drug or 10 ml of suspension are prescribed 2 times a day. Patients weighing more than 60 kg are prescribed the drug at the rate of 15 mg/kg/day. This dose is divided into 2 doses.
For cystic echinococcosis, the treatment is 28 days. The cycle can be re-appointed after the previous course in 2 weeks. With inoperable and multiple cysts, up to 3 cycles of 28 days are prescribed for the treatment of pulmonary, peritoneal, and hepatic cysts. If the cysts have another localization - in the brain, bones - longer treatment is prescribed. Before surgery, 2 cycles of 28 days are recommended. If the operation needs to be performed before the cycles are completed, the treatment is continued before the operation. After the operation and percutaneous drainage of the cysts, if a short course of treatment was carried out before the operation or in case of emergency surgery, 2 cycles of 28 days, separated by a break of 2 weeks, are carried out. When viable cysts or the spread of helminths are detected, treatment is carried out in 2 full cycles.
In case of alveolar echinococcosis, the treatment is 28 days. After 2 weeks, a repeat course lasting 28 days is held. If necessary, the treatment can be extended for several months or years. With neurocysticercosis, the duration of Zentel reception is 7-30 days, the duration of reception depends on the response to treatment. After 2 weeks, you can repeat the course. With cysts in the parenchyma, granulomas, the duration of treatment is about 7-28 days.
With racemose cysts, the treatment lasts at least 28 days. The duration of the treatment is determined by radiological and clinical response to the treatment. With capillariosis, 400 mg is prescribed per day for 10 days. As a rule, 1 course of treatment is enough, but with a positive result of the parasitological examination, an additional course may be required. With gnathostomosis, 400 mg per day is prescribed for 10-20 days. With trichinellosis, toxocarosis, take 400 mg per day for 5-10 days.
In the treatment of neurocysticercosis, it is recommended to prescribe anticonvulsant and GCS therapy. GCS are prescribed to prevent cerebral hypertension in the first week of treatment.
Prior to treatment with Zentel, patients with liver failure should be carefully examined. Albendazole is metabolized to an active metabolite in the liver, so liver dysfunction can significantly affect the pharmacokinetics of albendazole. If during treatment the level of transaminases increases significantly, or the blood parameters decrease, the treatment should be stopped.
Side effects
Immune system: reactions of increased sensitivity - itching, rash, urticaria.
CNS: dizziness and headache.
GIT: nausea, vomiting, as well as abdominal pain, diarrhea.
Hepatobiliary system: increased level of liver enzymes, rarely hepatitis.
Skin and subcutaneous tissue: Stevens-Johnson syndrome, polymorphic erythema, reversible alopecia.
Blood system, lymphatic system: leukopenia, rarely agranulocytosis, aplastic anemia, pancytopenia.
General disorders: fever.
Contraindications
A contraindication to the use of Zentel is increased sensitivity to albendazole. The drug is not recommended for children under 1 year of age in any form, tablets are contraindicated for children under 3 years of age.
Pregnancy
Zentel is contraindicated for use during pregnancy, breastfeeding and for the treatment of women who are planning pregnancy. albendazole, increasing the risk of overdose. The systemic action of the drug increases its intake with fatty food, increasing absorption.
Overdose
Symptoms of overdose, depending on the dose, may include nausea, diarrhea, vomiting, as well as tachycardia and increased transaminase levels.
Production
Tablets of 400 mg, No. 1. Suspensions for internal use in bottles of 400 mg/10 ml, No. 1.
Storage conditions
Suspension and tablets should be stored at a temperature of no more than 25 degrees Celsius, protect the packaging from direct sunlight.
Synonyms
Albendazole.
See also the list of drug analogues Zentel.
Composition
Albendazole in the amount of 400 mg/10 ml.
Auxiliary ingredients: sodium carboxymethyl starch, aluminum magnesium silicate, polysorbate 80, glycerol, benzoic acid, potassium sorbate, sorbitan monolaurate, silicone antifoam 1510, sorbic acid, saccharin sodium, flavoring, flavor additives.
Zentel, Zentel GlaxoSmithKline, It acts on intestinal and tissue forms of parasites, Ayurveda Here
